Potent activity of ponatinib (AP24534) in models of FLT3-driven acute myeloid leukemia (AML) and other hematologic malignancies
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چکیده
s) 2009;114:636. on June 19, 2017. © 2011 American Association for Cancer Research.mct.aacrjournals.orgDownloaded fromAuthor manuscripts have been peer reviewed and accepted for publication but have not yet been edited.Author Manuscript Published OnlineFirst on April 11, 2011; DOI: 10.1158/1535-7163.MCT-10-1044
منابع مشابه
Potent activity of ponatinib (AP24534) in models of FLT3-driven acute myeloid leukemia and other hematologic malignancies.
Ponatinib (AP24534) is a novel multitargeted kinase inhibitor that potently inhibits native and mutant BCR-ABL at clinically achievable drug levels. Ponatinib also has in vitro inhibitory activity against a discrete set of kinases implicated in the pathogenesis of other hematologic malignancies, including FLT3, KIT, fibroblast growth factor receptor 1 (FGFR1), and platelet derived growth factor...
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تاریخ انتشار 2011